Hacienda Misne was constructed during an era marked by global exploration that defined much of the 15th through the 17th centuries.

Hacienda Misne was originally a Yucatecan hacienda that dated back to the 18th century. Utilized as farming and manufacturing centers that produced meat and crops, haciendas were built by wealthy landowners from the late 1600s to the early 1900s. Haciendas became communities for the hundreds of workers and families that inhabited the area. The main house was occupied by the hacendado, while machine houses, chapels, storage buildings, living quarters, schools, infirmaries, stores, churches, cemeteries, jails, and stables were peppered across the rolling hills.

The Castro Alonzo family inhabited the stunning Hacienda Misne during the 1900s, aiming to enjoy the serenity just outside Merida City. This home became a private sanctuary where the three children could play in the abundant gardens that surrounded the Main House. Eventually, Hacienda Misne was renovated as a hotel using Gothic Revival-style architecture. After this change, guests were invited by the owners, Don José Castro and Doña Josefina Alonzo, for lunches, weekend stays, and Catholic masses. The celebrated tenor Nicolas Urcelay Alnozo, perhaps the most popular singer from the Epoque era, stayed at Hacienda Misne for an entire season.

In 1988, the Millet family purchased Hacienda Misne with the goal of preserving the famed traditional Yucatan hospitality for visitors from around the world. For 14 years, the hotel was transformed into a beautiful luxury resort boasting a historic atmosphere. French tiles, restored antique furniture, and Mayan architectural techniques were utilized to achieve such a feat. This magnificent holiday destination finally debuted before the public in 2007. Today, this historic hotel is under the same ownership that still provides the best historic vacation experience.